Sang Joon Lee
Pohang University of Science & Technology, South Korea
Title: In vivo velocity field measurements of circulatory blood flows using X-ray PIV technique
Biography
Biography: Sang Joon Lee
Abstract
In vivo measurement of hemodynamic information from real blood flows in arteries is very important for investigating the pathologies of circulatory vascular diseases. Especially in vivo experiments using animal disease models are essential for investigating the effects of various clinical treatments on hemodynamic parameters in the animal models. To get hemodynamic information of various cardiovascular diseases (CVDs), X-ray PIV (particle image velocimetry) technique in which X-ray beam is used as a transmissiontype light source was developed. At first, the feasibility of the X-ray PIV technique for measuring blood flows was confirmed through in vitro tests. Then surface-modified gold nanoparticles and biocompatible CO2 microbubbles were developed as tracer particles of blood flows. The X-ray PIV was found to have high temporal and spatial resolution to measure real pulsatile blood flows in a nondestructive manner with micrometer resolution. For in vivo X-ray PIV measurements, tracer particles were injected into rat models directly or to the extracorporeal loop connecting a microtube between the jugular vein and abdominal artery of a rat model. The velocity field information of real pulsatile blood flows was obtained with varying flow rate and pulsatility. This new advanced flow visualization technique could be effectively used to investigate hemodynamic and hemorheological features of blood flows related with CVDs.